The putative polymerase sequence of infectious salmon anemia virus suggests a new genus within the Orthomyxoviridae.

ABSTRACT: The infectious salmon anemia virus (ISAV) is an orthomyxovirus-like virus infecting teleosts. The disease caused by this virus has had major economic consequences for the Atlantic salmon farming industry in Norway, Canada, and Scotland. In this work, we report the cloning and sequencing of an ISAV-specific cDNA comprising 2,245 bp with an open reading frame coding for a predicted protein with a calculated molecular weight of 80.5 kDa. The putative protein sequence shows the core polymerase motifs characteristic of all viral RNA-dependent RNA polymerases. Comparison of the conserved motifs with the corresponding regions of other segmented negative-stranded RNA viruses shows a closer relationship with members of the Orthomyxoviridae than with viruses in other families. The putative ISAV poly

SUBMITTER: Krossoy B 

PROVIDER: S-EPMC104458 | biostudies-literature | 1999 Mar

REPOSITORIES: biostudies-literature