Lateral flow immunoassay-based laboratory algorithm for rapid diagnosis of diphtheria.

ABSTRACT: Background: In industrialised countries diphtheria is a rare but still life-threatening disease with a recent increase in cases due to migration and zoonotic aspects. Due to the rarity of the disease, laboratory diagnosis of diphtheria is often carried out in central reference laboratories and involves the use of sophisticated equipment and specially trained personnel. The result of the diphtheria agent detection can usually be obtained after 5-6 days or more. Authors suggest a Lateral Flow Immunoassay (LFIA)-based laboratory algorithm for the diagnosis of diphtheria, which may render less time in issuing a result and could promote the testing be performed in laboratories closer to the patient. Methods: LFIA for diphtheria toxin (DT) detection was designed using a pair of mon

SUBMITTER: Melnikov VG 

PROVIDER: S-EPMC10445807 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature