Trends in the epidemiology of childhood nephrotic syndrome in Africa: A systematic review.

ABSTRACT:

Background

Childhood nephrotic syndrome, if left untreated, leads to progressive kidney disease or death. We quantified the prevalence of steroid-sensitive nephrotic syndrome, steroid-resistant nephrotic syndrome, and histological types as the epidemiology of nephrotic syndrome in Africa remains unknown, yet impacts outcomes.

Methods

We searched MEDLINE, Embase, African Journals Online, and WHO Global Health Library for articles in any language reporting on childhood nephrotic syndrome in Africa from January 1, 1946 to July 1, 2020. Primary outcomes included steroid response, biopsy defined minimal change disease, and focal segmental glomerulosclerosis (FSGS) by both pooled and individual proportions across regions and overall.

Findings

There were 81 papers from 17 co

SUBMITTER: Wine R 

PROVIDER: S-EPMC10445969 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature