Longitudinal effects of lipid indices on incident cardiovascular diseases adjusting for time-varying confounding using marginal structural models: 25 years follow-up of two US cohort studies.

ABSTRACT:

Background

This study assesses the effect of blood lipid indices and lipid ratios on cardiovascular diseases (CVDs) using inverse probability-of-exposure weighted estimation of marginal structural models (MSMs).

Methods

A pooled dataset of two US representative cohort studies, including 16736 participants aged 42-84 years with complete information at baseline, was used. The effect of each lipid index, including low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), ratios of TC/HDL-C, LDL-C/HDL-C, and TG/HDL-C on coronary heart disease (CHD) and stroke were estimated using weighted Cox regression.

Results

There were 1638 cases of CHD and 1017 cases of stroke during a median follow-up of 17.1 years (interquartile r

SUBMITTER: Koohi F 

PROVIDER: S-EPMC10445971 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature