Altered composition of the mitochondrial Ca²⁺uniporter in the failing human heart.

ABSTRACT: Heart failure (HF) is a leading cause of hospitalization and mortality worldwide. Yet, there is still limited knowledge on the underlying molecular mechanisms, because human tissue for research is scarce, and data obtained in animal models is not directly applicable to humans. Thus, studies of human heart specimen are of particular relevance. Mitochondrial Ca²⁺ handling is an emerging topic in HF progression because its regulation is central to the energy supply of the heart contractions as well as to avoiding mitochondrial Ca²⁺ overload and the ensuing cell death induction. Notably, animal studies have already linked impaired mitochondrial Ca²⁺ transport to the initiation/progression of HF. Mitochondrial Ca²⁺ uptake is mediated by the Ca^2+<

SUBMITTER: Paillard M 

PROVIDER: S-EPMC10446164 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature