Functional and spatial rewiring principles jointly regulate context-sensitive computation.

ABSTRACT: Adaptive rewiring provides a basic principle of self-organizing connectivity in evolving neural network topology. By selectively adding connections to regions with intense signal flow and deleting underutilized connections, adaptive rewiring generates optimized brain-like, i.e. modular, small-world, and rich club connectivity structures. Besides topology, neural self-organization also follows spatial optimization principles, such as minimizing the neural wiring distance and topographic alignment of neural pathways. We simulated the interplay of these spatial principles and adaptive rewiring in evolving neural networks with weighted and directed connections. The neural traffic flow within the network is represented by the equivalent of diffusion dynamics for directed edges: consensus and ad

SUBMITTER: Li J 

PROVIDER: S-EPMC10446201 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature