Tregs depletion aggravates activation of astrocytes by modulating IL-10/GXP4 following cerebral infarction.

ABSTRACT:

Background

Tregs plays a critical role in the development of secondary injuries in diseases. Accumulating evidence suggests an association between ischemic stroke and renal dysfunction; however, the underlying mechanisms remain unclear. This study aimed to investigate the potential of Tregs in inhibiting the activation of astrocytes after focal cerebral infarction.

Methods

This study aimed to investigate the renal consequences of focal cerebral ischemia by subjecting a mouse model to transient middle cerebral artery occlusion (tMCAO). Subsequently, we assessed renal fibrosis, renal ferroptosis, Treg infiltration, astrocyte activation, as well as the expression levels of active GPX4, FSP1, IL-10, IL-6, and IL-2 after a 2-week period.

Results

In the tMCAO mouse model, d

SUBMITTER: Wang S 

PROVIDER: S-EPMC10446222 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature