Clinical predictors of encephalitis in UK adults-A multi-centre prospective observational cohort study.

ABSTRACT:

Objectives

Encephalitis, brain inflammation and swelling, most often caused by an infection or the body's immune defences, can have devastating consequences, especially if diagnosed late. We looked for clinical predictors of different types of encephalitis to help clinicians consider earlier treatment.

Methods

We conducted a multicentre prospective observational cohort study (ENCEPH-UK) of adults (> 16 years) with suspected encephalitis at 31 UK hospitals. We evaluated clinical features and investigated for infectious and autoimmune causes.

Results

341 patients were enrolled between December 2012 and December 2015 and followed up for 12 months. 233 had encephalitis, of whom 65 (28%) had HSV, 38 (16%) had confirmed or probable autoimmune encephalitis, and 87 (37%) had

SUBMITTER: Defres S 

PROVIDER: S-EPMC10446234 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature