Oxylipin concentration shift in exhaled breath condensate (EBC) of SARS-CoV-2 infected patients.

ABSTRACT: Infection of airway epithelial cells with severe acute respiratory coronavirus 2 (SARS-CoV-2) can lead to severe respiratory tract damage and lung injury with hypoxia. It is challenging to sample the lower airways non-invasively and the capability to identify a highly representative specimen that can be collected in a non-invasive way would provide opportunities to investigate metabolomic consequences of COVID-19 disease. In the present study, we performed a targeted metabolomic approach using liquid chromatography coupled with high resolution chromatography (LC-MS) on exhaled breath condensate (EBC) collected from hospitalized COVID-19 patients (COVID+) and negative controls, both non-hospitalized and hospitalized for other reasons (COVID-). We were able to noninvasively identify and quan

SUBMITTER: Borras E 

PROVIDER: S-EPMC10446499 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature