Intravesical hyaluronic acid with chondroitin sulphate to prevent urinary tract infection after spinal cord injury.

ABSTRACT:

Context/objective

Prevention of urinary tract infection (UTI) after spinal cord injury is an important goal. Intravesical hyaluronic acid with chondroitin sulphate (HA+CS) has been effective in preventing UTI in other settings. We aimed to demonstrate safety and feasibility of a standard treatment course of 7 intravesical HA+CS instillations over 12 weeks, in patients with acute (Arm A) and chronic (Arm B) spinal cord injury (SCI).

Design

Follow-up of adverse events, quality of life bladder management difficulty (BMD) and bladder complication (BC) T-scores at baseline (Arm B only), 12 and 24 weeks, and symptomatic urinary tract infection (UTI).

Results

Of 33 and 14 individuals screened, 2 and 8 participants were recruited to the study for Arm A and Arm B respec

SUBMITTER: King GK 

PROVIDER: S-EPMC10446783 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature