Distinct Origins and Transmission Pathways of <i>bla</i>_KPC <i>Enterobacterales</i> across Three U.S. States.

ABSTRACT: Carbapenem-resistant Enterobacterales (CRE) are among the most concerning antibiotic resistance threats due to high rates of multidrug resistance, transmissibility in health care settings, and high mortality rates. We evaluated the potential for regional genomic surveillance to track the spread of bla_KPC-carrying CRE (KPC-CRE) by using isolate collections from health care facilities in three U.S. states. Clinical isolates were collected from Connecticut (2017 to 2018), Minnesota (2012 to 2018), and Tennessee (2016 to 2017) through the U.S. Centers for Disease Control and Prevention's Multi-site Gram-negative Surveillance Initiative (MuGSI) and additional surveillance. KPC-CRE isolates were whole-genome sequenced, yielding 255 isolates from 214 patients across 96 fa

SUBMITTER: Lapp Z 

PROVIDER: S-EPMC10446861 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature