Redlining-associated methylation in breast tumors: the impact of contemporary structural racism on the tumor epigenome.

ABSTRACT:

Purpose

Place-based measures of structural racism have been associated with breast cancer mortality, which may be driven, in part, by epigenetic perturbations. We examined the association between contemporary redlining, a measure of structural racism at the neighborhood level, and DNA methylation in breast tumor tissue.

Methods

We identified 80 Black and White women diagnosed and treated for a first-primary breast cancer at Emory University Hospitals (2008-2017). Contemporary redlining was derived for census tracts using the Home Mortgage Disclosure Act database. Linear regression models were used to calculate the association between contemporary redlining and methylation in breast tumor tissue. We also examined epigenetic age acceleration for two different metrics, regressi

SUBMITTER: Miller-Kleinhenz JM 

PROVIDER: S-EPMC10446968 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature