Significance of programmed death-ligand 1 expression in resected lung cancer and its relationship with EGFR mutation.

ABSTRACT:

Background

Several studies have reported that the high expression of programmed death-ligand 1 (PD-L1) within tumor cells predicts a poor prognosis. However, the relationship between the PD-L1 expression and lymph node metastasis or driver mutations in lung cancer remains poorly understood.

Methods

A total of 356 consecutive patients who underwent surgical resection for primary lung cancer were included in the study. There were 268 adenocarcinomas including 100 EGFR mutations, 67 squamous cell carcinomas (Sq), and 21 other histologies. The high expression of PD-L1 was defined as a tumor proportion score (TPS) of ≥50. The relationship between the PD-L1 expression and clinicopathological factors and recurrence-free survival (RFS) was analyzed.

Results

The PD-L1 expressi

SUBMITTER: Osoegawa A 

PROVIDER: S-EPMC10447166 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature