A modal definition of ideal alveolar oxygen.

ABSTRACT: In the three-compartment model of lung ventilation-perfusion heterogeneity (VA/Q scatter), both Bohr dead space and shunt equations require values for central "ideal" compartment O₂ and CO₂ partial pressures. However, the ideal alveolar gas equation most accurately calculates mixed (ideal and alveolar dead space) PAO₂ . A novel "modal" definition has been validated for ideal alveolar CO₂ partial pressure, at the VA/Q ratio in a lung distribution where CO₂ elimination is maximal. A multicompartment computer model of physiological, lognormal distributions of VA and Q was used to identify modal "ideal" PAO₂ , and find a modification of the alveolar gas equation to estimate it across a wide range of severity of VA/Q heterogeneit

SUBMITTER: Peyton PJ 

PROVIDER: S-EPMC10447219 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature