Ontology highlight
ABSTRACT:
SUBMITTER: Tai YH
PROVIDER: S-EPMC10447243 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Nature metabolism 20230710 8
Inflammation in the central nervous system can impair the function of neuronal mitochondria and contributes to axon degeneration in the common neuroinflammatory disease multiple sclerosis (MS). Here we combine cell-type-specific mitochondrial proteomics with in vivo biosensor imaging to dissect how inflammation alters the molecular composition and functional capacity of neuronal mitochondria. We show that neuroinflammatory lesions in the mouse spinal cord cause widespread and persisting axonal A ...[more]