A Physiology-Based Mathematical Model to Understand Drug Delivery from Contact Lenses to the Back of the Eye.

ABSTRACT:

Objective

Therapeutic contact lenses, able to store drug and deliver it to the eye surface in a sustained fashion, gained interest as an effective and patient-friendly alternative to eye drops. Recent animal studies also demonstrated the presence of therapeutic drug levels in the back of the eye after wearing drug-loaded contact lenses, thus opening the possibility of treating the posterior segment without need of invasive intraocular injections. The drug pathways from contact lenses to the back of the eye require further investigation.

Methods

A mechanistic mathematical model was developed to evaluate the drug concentration over time in the tears, sclera and choroid, retina, aqueous humor and vitreous humor after the application of a therapeutic contact lens. The main drug

SUBMITTER: Toffoletto N 

PROVIDER: S-EPMC10447275 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature