Type-2 CD8⁺ T-cell formation relies on interleukin-33 and is linked to asthma exacerbations.

ABSTRACT: CD4⁺ T helper 2 (Th2) cells and group 2 innate lymphoid cells are considered the main producers of type-2 cytokines that fuel chronic airway inflammation in allergic asthma. However, CD8⁺ cytotoxic T (Tc) cells - critical for anti-viral defense - can also produce type-2 cytokines (referred to as 'Tc2' cells). The role of Tc cells in asthma and virus-induced disease exacerbations remains poorly understood, including which micro-environmental signals and cell types promote Tc2 cell formation. Here we show increased circulating Tc2 cell abundance in severe asthma patients, reaching peak levels during exacerbations and likely emerging from canonical IFNγ⁺ Tc cells through plasticity. Tc2 cell abundance is associated with increased disease burden, higher exacerb

SUBMITTER: van der Ploeg EK 

PROVIDER: S-EPMC10447424 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature