Bacterial lipopolysaccharide modulates immune response in the colorectal tumor microenvironment.

ABSTRACT: Immune responses can have opposing effects in colorectal cancer (CRC), the balance of which may determine whether a cancer regresses, progresses, or potentially metastasizes. These effects are evident in CRC consensus molecular subtypes (CMS) where both CMS1 and CMS4 contain immune infiltrates yet have opposing prognoses. The microbiome has previously been associated with CRC and immune response in CRC but has largely been ignored in the CRC subtype discussion. We used CMS subtyping on surgical resections from patients and aimed to determine the contributions of the microbiome to the pleiotropic effects evident in immune-infiltrated subtypes. We integrated host gene-expression and meta-transcriptomic data to determine the link between immune characteristics and microbiome contributions in

SUBMITTER: Sulit AK 

PROVIDER: S-EPMC10447454 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature