Age-dependent associations of human milk oligosaccharides with body size and composition up to 4 years of age.

ABSTRACT:

Background

Human milk oligosaccharides (HMOs) are major components of human milk that may mediate its beneficial effects on infant growth.

Objectives

To investigate relationships between HMO concentrations in milk at 6 wk postpartum and anthropometry to 4 y of age in human milk-fed infants.

Methods

Milk samples were collected from 292 mothers at 6 wk (median 6.0 wk; range 3.3, 11.1] postpartum in a longitudinal, population-derived cohort. Of the infants, 171 were exclusively human milk-fed to 3 mo of age and 127 to 6 mo. Concentrations of 19 HMOs were quantified using high-performance liquid chromatography. Maternal secretor status (n = 221 secretors) was determined from 2'-fucosyllactose (2'FL) concentration. We calculated z-scores for child weight, length, head circ

SUBMITTER: Mansell T 

PROVIDER: S-EPMC10447468 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature