Moderate consumption of freeze-dried blueberry powder increased net bone calcium retention compared with no treatment in healthy postmenopausal women: a randomized crossover trial.

ABSTRACT:

Background

Preclinical studies suggest that blueberry consumption is associated with improved bone health.

Objectives

We conducted a blueberry dose-response study in ovariectomized (OVX)-rats that informed a study in postmenopausal women using the urinary appearance of calcium (Ca) tracers from prelabeled bone to reflect changes in bone balance. We hypothesized that blueberry consumption would reduce bone loss in a dose-dependent manner compared with no treatment.

Methods

OVX rats were fed 4 doses of blueberry powder (2.5%, 5%, 10%, and 15%) in randomized order to determine bone ⁴⁵Ca retention. Fourteen healthy, nonosteoporotic women ≥4 y past menopause were dosed with 50 nCi of ⁴¹Ca, a long-lived radioisotope, and equilibrated for 5 mo to allow

SUBMITTER: Hodges JK 

PROVIDER: S-EPMC10447493 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature