Exploring the mechanism of luteolin by regulating microglia polarization based on network pharmacology and in vitro experiments.

ABSTRACT: Neuroinflammation manifests following injury to the central nervous system (CNS) and M1/M2 polarization of microglia is closely associated with the development of this neuroinflammation. In this study, multiple databases were used to collect targets regarding luteolin and microglia polarization. After obtaining a common target, a protein-protein interaction (PPI) network was created and further analysis was performed to obtain the core network. Molecular docking of the core network with luteolin after gene enrichment analysis. In vitro experiments were used to examine the polarization of microglia and the expression of related target proteins. A total of 77 common targets were obtained, and the core network obtained by further analysis contained 38 proteins. GO and KEGG analyses revealed t

SUBMITTER: Wang T 

PROVIDER: S-EPMC10447507 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature