ALKBH5 promotes hypopharyngeal squamous cell carcinoma apoptosis by targeting TLR2 in a YTHDF1/IGF2BP2-mediated manner.

ABSTRACT: Hypopharyngeal squamous cell carcinoma (HPSCC) is one of the most aggressive cancers and is notorious for its extremely poor prognosis. However, very few molecular biological studies have been performed. As a novel method of epigenetic gene modulation, N6-methyladenosine (m⁶A) RNA modification occurs in HPSCC. The expression of the m⁶A demethylase AlkB homolog 5 (ALKBH5) is frequently downregulated in human HPSCC. Furthermore, we found that ALKBH5 impaired cell proliferation by regulating human Toll-like receptor 2 (TLR2) in an m⁶A-dependent manner in HPSCC cells. ALKBH5 decreased TLR2 m⁶A modification, which could be recognized by the m⁶A readers IGF2BP2 and YTHDF1. IGF2BP2 facilitates TLR2 mRNA stability, whereas YTHDF1 promotes TLR2

SUBMITTER: Ye J 

PROVIDER: S-EPMC10447508 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature