Ontology highlight
ABSTRACT:
SUBMITTER: Langella S
PROVIDER: S-EPMC10447560 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Langella Stephanie S Barksdale N Gil NG Vasquez Daniel D Aguillon David D Chen Yinghua Y Su Yi Y Acosta-Baena Natalia N Acosta-Uribe Juliana J Baena Ana Y AY Garcia-Ospina Gloria G Giraldo-Chica Margarita M Tirado Victoria V Muñoz Claudia C Ríos-Romenets Silvia S Guzman-Martínez Claudia C Oliveira Gabriel G Yang Hyun-Sik HS Vila-Castelar Clara C Pruzin Jeremy J JJ Ghisays Valentina V Arboleda-Velasquez Joseph F JF Kosik Kenneth S KS Reiman Eric M EM Lopera Francisco F Quiroz Yakeel T YT
Nature communications 20230823 1
Autosomal dominant Alzheimer's disease (ADAD) is genetically determined, but variability in age of symptom onset suggests additional factors may influence cognitive trajectories. Although apolipoprotein E (APOE) genotype and educational attainment both influence dementia onset in sporadic AD, evidence for these effects in ADAD is limited. To investigate the effects of APOE and educational attainment on age-related cognitive trajectories in ADAD, we analyzed data from 675 Presenilin-1 E280A mutat ...[more]