Persistent symptoms after COVID-19 are not associated with differential SARS-CoV-2 antibody or T cell immunity.

ABSTRACT: Among the unknowns in decoding the pathogenesis of SARS-CoV-2 persistent symptoms in Long Covid is whether there is a contributory role of abnormal immunity during acute infection. It has been proposed that Long Covid is a consequence of either an excessive or inadequate initial immune response. Here, we analyze SARS-CoV-2 humoral and cellular immunity in 86 healthcare workers with laboratory confirmed mild or asymptomatic SARS-CoV-2 infection during the first wave. Symptom questionnaires allow stratification into those with persistent symptoms and those without for comparison. During the period up to 18-weeks post-infection, we observe no difference in antibody responses to spike RBD or nucleoprotein, virus neutralization, or T cell responses. Also, there is no difference in the profile o

SUBMITTER: Altmann DM 

PROVIDER: S-EPMC10447583 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature