Single-dose pharmacokinetics and lung function of nebulized niclosamide ethanolamine in sheep.

ABSTRACT:

Purpose

Niclosamide is approved as an oral anthelminthic, but its low oral bioavailability hinders its medical use requiring high drug exposure outside the gastrointestinal tract. An optimized solution of niclosamide for nebulization and intranasal administration using the ethanolamine salt has been developed and tested in a Phase 1 trial. In this study we investigate the pulmonary exposure of niclosamide following administration via intravenous injection, oral administration or nebulization.

Methods

We characterized the plasma and pulmonary pharmacokinetics of three ascending doses of nebulized niclosamide in sheep, compare it to intravenous niclosamide for compartmental PK modelling, and to the human equivalent approved 2 g oral dose to investigate in the pulmonary exposur

SUBMITTER: Weiss A 

PROVIDER: S-EPMC10447587 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature