Metabolomic Profiling of an Ultraprocessed Dietary Pattern in a Domiciled Randomized Controlled Crossover Feeding Trial.

ABSTRACT:

Background

Objective markers of ultraprocessed foods (UPF) may improve the assessment of UPF intake and provide insight into how UPF influences health.

Objectives

To identify metabolites that differed between dietary patterns (DPs) high in or void of UPF according to Nova classification.

Methods

In a randomized, crossover, controlled-feeding trial (clinicaltrials.govNCT03407053), 20 domiciled healthy participants (mean ± standard deviation: age 31 ± 7 y, body mass index [kg/m²] 22 ± 11.6) consumed ad libitum a UPF-DP (80% UPF) and an unprocessed DP (UN-DP; 0% UPF) for 2 wk each. Metabolites were measured using liquid chromatography with tandem mass spectrometry in ethylenediaminetetraacetic acid plasma, collected at week 2 and 24-h, and spot urine, collecte

SUBMITTER: O'Connor LE 

PROVIDER: S-EPMC10447619 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature