Ontology highlight
ABSTRACT:
SUBMITTER: Rhee C
PROVIDER: S-EPMC10447620 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Rhee Catherine C Scadden Elizabeth W EW Wong Lai Ping LP Schiroli Giulia G Mazzola Michael C MC Chea Phillip L PL Kato Hiroki H Hoyer Friedrich F FF Mistry Meeta M Lee Bum-Kyu BK Kim Jonghwan J Nahrendorf Matthias M Mansour Michael K MK Sykes David B DB Sadreyev Ruslan I RI Scadden David T DT
Blood 20230801 7
Myeloid cell heterogeneity is known, but whether it is cell-intrinsic or environmentally-directed remains unclear. Here, an inducible/reversible system pausing myeloid differentiation allowed the definition of clone-specific functions that clustered monocytes into subsets with distinctive molecular features. These subsets were orthogonal to the classical/nonclassical categorization and had inherent, restricted characteristics that did not shift under homeostasis, after irradiation, or with infec ...[more]