Can Superoxide Anions Predict the Malignant Potential of Carotid body Tumor? - A Pilot Study.

ABSTRACT: Currently, there is no consensus on estimating the malignant potential of Carotid Body Tumor (CBT) and the only way to predict a metastatic CBT is through DOTANOC Positron Emission Tomography (PET) scan. There is a well-established correlation between CBT and superoxide anions inside tumor cells. The purpose of this pilot study was to measure superoxide anions inside CBT cells and find if these can be used as marker to predict malignant potential of CBT. The results were also co-related with findings of DOTANOC PET scan retrospectively. The CBT tissue from 10 patients was stained using a fluorogenic dye and superoxide anions were measured by analysis of fluorescent image. The patients were divided into two groups - First group with four patients having potentially malignant CBT based upon

SUBMITTER: Kajal S 

PROVIDER: S-EPMC10447714 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature