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Oxidized cellulose-based reaction mimicking thyroidal recurrence of disease: a case report and literature review.


ABSTRACT: Oxidized cellulose is a hemostatic agent currently used in surgery. Foreign body reactions have been described after its use. This paper describes a foreign body reaction caused by oxidized cellulose in a young woman who underwent thyroid surgery. A patient underwent two thyroid surgeries for treatment of papillary carcinoma. Five years after the last surgery, an asymptomatic mass was detected with a routine ultrasound in the left thyroid cavity. After surgical removal, the mass turned out to be a foreign body granuloma based on oxidized cellulose sheets used in the previous surgery. The patient was discharged from the hospital without complications. The follow-up period was uneventful. Oxidized cellulose is a useful tool in surgery to control and prevent intra and post-operative bleeding. Even if it is a biodegradable material, sometimes it persists in the human body causing foreign body reactions that can be misdiagnosed.

Supplementary information

The online version contains supplementary material available at 10.1007/s12070-023-03556-0.

SUBMITTER: Liberale C 

PROVIDER: S-EPMC10447742 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature

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Oxidized cellulose-based reaction mimicking thyroidal recurrence of disease: a case report and literature review.

Liberale Carlotta C   Segato Erika E   Sacchetto Andrea A   Silvestrini Marina M   Saetti Roberto R  

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India 20230408 3


Oxidized cellulose is a hemostatic agent currently used in surgery. Foreign body reactions have been described after its use. This paper describes a foreign body reaction caused by oxidized cellulose in a young woman who underwent thyroid surgery. A patient underwent two thyroid surgeries for treatment of papillary carcinoma. Five years after the last surgery, an asymptomatic mass was detected with a routine ultrasound in the left thyroid cavity. After surgical removal, the mass turned out to be  ...[more]

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