Immune changes induced by periampullary adenocarcinoma are reversed after tumor resection and modulate the postoperative survival.

ABSTRACT:

Background

Tumor growth encompasses multiple immunologic processes leading to impaired immunity. Regarding cancer surgery, the perioperative period is characterized by additional immunosuppression, which may contribute to poorer outcomes. In this exploratory study, we assessed plasma parameters characterizing the perioperative immunity with a particular focus on their prognostic value.

Patients and methods

31 patients undergoing pancreatoduodenectomy were enrolled (adenocarcinoma of the pancreatic head and its periampullary region: n = 24, benign pancreatic diseases n = 7). Abundance and function of circulating immune cells and the plasma protein expression were analyzed in blood samples taken pre- and postoperatively using flow cytometry, ELISA and Proximity Extension Assay

SUBMITTER: Landerer A 

PROVIDER: S-EPMC10447764 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature