Glucose controls manganese homeostasis through transcription factors regulating known and newly identified manganese transporter genes in Bacillus subtilis.

ABSTRACT: Mn²⁺ is an essential nutrient whose concentration is tightly controlled in bacteria. In Bacillus subtilis, the Mn²⁺-activated transcription factor MntR controls Mn²⁺ transporter genes. However, factors regulating intracellular Mn²⁺ concentration are incompletely understood. Here, we found that glucose addition induces an increase in intracellular Mn²⁺ concentration. We determined this upshift was mediated by glucose induction of the major Mn²⁺ importer gene mntH by the transcription factor AhrC, which is known to be involved in arginine metabolism and to be indirectly induced by glucose. In addition, we identified novel AhrC-regulated genes encoding the Mn²⁺ importer YcsG and the ABC-type exporter YknUV. We found

SUBMITTER: Ogura M 

PROVIDER: S-EPMC10448178 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature