Divergent roles of estrogen receptor subtypes in regulating estrogen-modulated colonic ion transports and epithelial repair.

ABSTRACT: Although it was described previously for estrogen (E₂) regulation of intestinal epithelial Cl^- and HCO₃^- secretion in sex difference, almost nothing is known about the roles of estrogen receptor (ER) subtypes in regulating E₂-modulated epithelial ion transports and epithelial restitution. Here, we aimed to investigate ERα and ERβ subtypes in the regulation of E₂-modulated colonic epithelial HCO₃^- and Cl^- secretion and epithelial restitution. Through physiological and biochemical studies, in combination of genetic knockdown, we showed that ERα attenuated female colonic Cl^- secretion but promoted Ca²⁺-dependent HCO₃^- secretion via store-operated calci

SUBMITTER: Wan H 

PROVIDER: S-EPMC10448179 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature