Advances in the engineering of the outer blood-retina barrier: From in-vitro modelling to cellular therapy.

ABSTRACT: The outer blood-retina barrier (oBRB), crucial for the survival and the proper functioning of the overlying retinal layers, is disrupted in numerous diseases affecting the retina, leading to the loss of the photoreceptors and ultimately of vision. To study the oBRB and/or its degeneration, many in vitro oBRB models have been developed, notably to investigate potential therapeutic strategies against retinal diseases. Indeed, to this day, most of these pathologies are untreatable, especially once the first signs of degeneration are observed. To cure those patients, a current strategy is to cultivate in vitro a mature oBRB epithelium on a custom membrane that is further implanted to replace the damaged native tissue. After a description of the oBRB and the related diseases, this

SUBMITTER: Dujardin C 

PROVIDER: S-EPMC10448242 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature