Cavity architecture based modulation of ligand binding tunnels in plant START domains.

ABSTRACT: The Steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain represents an evolutionarily conserved superfamily of lipid transfer proteins widely distributed across the tree of life. Despite significant expansion in plants, knowledge about this domain remains inadequate in plants. In this work, we explore the role of cavity architectural modulations in START protein evolution and functional diversity. We use deep-learning approaches to generate plant START domain models, followed by surface accessibility studies and a comprehensive structural investigation of the rice START family. We validate 28 rice START domain models, delineate binding cavities, measure pocket volumes, and compare these with mamma

SUBMITTER: Mahtha SK 

PROVIDER: S-EPMC10448341 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature