Brown adipose tissue but not tibia exhibits a dramatic response to acute reduction in environmental temperature in growing male mice.

ABSTRACT: Mice are typically housed at room temperature (∼22 °C), which is well below their thermoneutral zone and results in cold stress. Chronic cold stress leads to increased adaptive thermogenesis and reductions in cancellous bone volume and bone marrow adipose tissue mass in long bones of growing mice. There is strong evidence that increased neuronal activity initiates the metabolic response of intrascapular brown adipose tissue (BAT) to cold stress, but it is less clear whether bone is regulated through a similar mechanism. Therefore, we compared the short-term response of BAT and whole tibia to a reduction in environmental temperature. To accomplish this, we transferred a group of 6-week-old male mice from 32 °C to 22 °C housing and sacrificed the mice 24 h later. Age-matched controls were ma

SUBMITTER: Wong CP 

PROVIDER: S-EPMC10448410 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature