A target-based discovery from a parasitic helminth as a novel therapeutic approach for autoimmune diseases.

ABSTRACT:

Background

Regulatory T cells (Tregs) can alleviate the development of autoimmune and inflammatory diseases, thereby proposing their role as a new therapeutic strategy. Parasitic helminths have co-evolved with hosts to generate immunological privilege and immune tolerance through inducing Tregs. Thus, constructing a "Tregs-induction"-based discovery pipeline from parasitic helminth is a promising strategy to control autoimmune and inflammatory diseases.

Methods

The gel filtration chromatography and reverse-phase high-performance liquid chromatography (RP-HPLC) were used to isolate immunomodulatory components from the egg extracts of Schistosoma japonicum. The extracted peptides were evaluated for their effects on Tregs suppressive functions using flow cytometry, ELISA and T

SUBMITTER: Ni Y 

PROVIDER: S-EPMC10448429 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature