A comparison of analytic approaches for investigating the obesity paradox in kidney cancer.

ABSTRACT:

Purpose

Body mass index (BMI) and kidney cancer mortality are inconsistently associated in the scientific literature. To understand how study design affects results, we contrasted associations between pre-diagnosis BMI and mortality under different analytic scenarios in a large, population-based prospective cohort study.

Methods

Using data from the NIH-AARP Diet and Health Study (1995-2011), we constructed two cohorts: a "full at-risk" cohort with no kidney cancer history at baseline (n = 252,845) and an "incident cancer" subset who developed kidney cancer during follow-up (n = 1,652). Cox Proportional Hazards models estimated hazard ratios (HR) and 95% confidence intervals (CI) between pre-diagnosis BMI and mortality for different outcomes (all-cause and cancer-specific mor

SUBMITTER: Olsson LT 

PROVIDER: S-EPMC10448500 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature