Elevated morbidity and mortality in patients with chronic idiopathic hypophosphatemia: a nationwide cohort study

ABSTRACT:

Background

Chronic idiopathic hypophosphatemia (CIH) induced by X-linked hypophosphatemic rickets or tumor-induced osteomalacia is a rare inherited or acquired disorder. However, due to its rarity, little is known about the epidemiology and natural course of CIH. Therefore, we aimed to identify the prevalence and long-term health outcomes of CIH patients.

Methods

Using the Korean Health Insurance Review and Assessment claims database, we evaluated the incidence of hypophosphatemia initially diagnosed from 2003 to 2018. After excluding secondary conditions that could change serum phosphorus levels, we identified 154 patients (76 men and 78 women) with non-secondary and non-renal hypophosphatemia. These hypophosphatemic patients were compared at a ratio of 1:10 with age-, s

SUBMITTER: Kim K 

PROVIDER: S-EPMC10448510 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature