Unraveling the transcriptome-based network of tfh cells in primary sjogren syndrome: insights from a systems biology approach.

ABSTRACT:

Background

Primary Sjogren Syndrome (pSS) is an autoimmune disease characterized by immune cell infiltration. While the presence of follicular T helper (Tfh) cells in the glandular microenvironment has been observed, their biological functions and clinical significance remain poorly understood.

Methods

We enrolled a total of 106 patients with pSS and 46 patients without pSS for this study. Clinical data and labial salivary gland (LSG) biopsies were collected from all participants. Histological staining was performed to assess the distribution of Tfh cells and B cells. Transcriptome analysis using RNA-sequencing (RNA-seq) was conducted on 56 patients with pSS and 26 patients without pSS to uncover the underlying molecular mechanisms of Tfh cells. To categorize patients, we em

SUBMITTER: Luo D 

PROVIDER: S-EPMC10448518 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature