Longitudinal trajectories of maternal TSH in healthy pregnant women in Catalonia.

ABSTRACT:

Objective

Longitudinal evaluation of thyroid function throughout pregnancy in the same subject could offer precise information about its dynamics as a physiological mechanism of adaption to the requirements. In this study, we evaluated longitudinal trajectories of maternal thyroid function during pregnancy by a latent class growth analysis and explored their association with maternal-fetal outcomes.

Methods

A prospective observational study was carried out, including 414 healthy pregnant women, from the first trimester to delivery. Thyroid function and autoimmunity were measured in the three trimesters. Clinical data during pregnancy were obtained. Longitudinal mixed model techniques were performed to explore trajectories of gestational thyroid function.

Results

Three

SUBMITTER: Soldevila B 

PROVIDER: S-EPMC10448591 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature