Sol-Gel-Controlled Size and Morphology of Mesoporous Silica Microspheres Using Hard Templates.

ABSTRACT: Mesoporous silica microspheres (MPSMs) represent a promising material as a stationary phase for HPLC separations. The use of hard templates provides a preparation strategy for producing such monodisperse silica microspheres. Here, 15 MPSMs were systematically synthesized by varying the sol-gel reaction parameters of water-to-precursor ratio and ammonia concentration in the presence of a porous p(GMA-co-EDMA) polymeric hard template. Changing the sol-gel process factors resulted in a wide range of MPSMs with varying particle sizes from smaller than one to several micrometers. The application of response surface methodology allowed to derive quantitative predictive models based on the process factor effects on particle size, pore size, pore volume, and specific surface area of

SUBMITTER: Steinbach JC 

PROVIDER: S-EPMC10448668 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature