Green Synthesis and Bioactivity of Aliphatic N-Substituted Glycine Derivatives.

ABSTRACT: Standard amino acids have an asymmetric α-carbon atom to which -COOH, -NH₂, -H, and -R groups are bonded. Among them, glycine is the simplest (R = -H) with no asymmetric carbon, and other natural amino acids are C-substituted of glycine. Here, we have designed and made a green synthesis of some new N-substituted glycine derivatives with R-(NH)CH₂-COOH formula, where R is flexible and hydrophobic with different chain lengths and benches of the type propyl, butyl, sec-butyl, tert-butyl, pentyl, isopentyl, tert-pentyl, hexyl, 2-aminoheptyl, and octyl. These glycine derivatives were characterized by recording their melting points and FT-IR, mass, ¹H NMR, and ¹³C NMR spectra. DFT studies revealed that 2-aminoheptyl glycine had the

SUBMITTER: Jafari A 

PROVIDER: S-EPMC10448692 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature