Vascular risk factors for idiopathic normal pressure hydrocephalus: a systematic review and meta-analysis.

ABSTRACT:

Objective

Idiopathic normal-pressure hydrocephalus (iNPH) is a treatable cause of dementia; however, its etiology and pathogenesis remain poorly understood. The objective of this study was to investigate the prevalence and impact of vascular risk factors in patients with iNPH compared to a control cohort to better understand the potential mechanisms and preventive measures.

Methods

We systematically searched PubMed, Web of Science, Embase, and the Cochrane Library (from inception to December 20, 2022) for studies reporting vascular risk factors for the development of iNPH. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using random-effects models.

Results

After screening 1,462 articles, 11 case-control studies comprising 1,048 patients with

SUBMITTER: Cai H 

PROVIDER: S-EPMC10448702 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature