Famotidine Enhances Rifampicin Activity against Acinetobacter baumannii by Affecting OmpA.

ABSTRACT: The development of novel antibiotic adjuvants is imminent because of the frequent emergence of resistance in Gram-negative bacteria, which severely restricts the efficiency and longevity of commonly used clinical antibiotics. It is reported that famotidine, a clinical inhibitor of gastric acid secretion, enhances the antibacterial activity of rifamycin antibiotics, especially rifampicin, against Gram-negative bacteria and reverses drug resistance. Studies have shown that famotidine disrupts the cell membrane of Acinetobacter baumannii and inhibits the expression of the outer membrane protein ompA gene, while causing a dissipation of the plasma membrane potential, compensatively upregulating the pH gradient and ultimately increasing the accumulation of reactive oxygen species by lead

SUBMITTER: Zhang MN 

PROVIDER: S-EPMC10448789 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature