IQGAP1 mediates the communication between the nucleus and the mitochondria via NDUFS4 alternative splicing.

ABSTRACT: Constant communication between mitochondria and nucleus ensures cellular homeostasis and adaptation to mitochondrial stress. Anterograde regulatory pathways involving a large number of nuclear-encoded proteins control mitochondrial biogenesis and functions. Such functions are deregulated in cancer cells, resulting in proliferative advantages, aggressive disease and therapeutic resistance. Transcriptional networks controlling the nuclear-encoded mitochondrial genes are known, however alternative splicing (AS) regulation has not been implicated in this communication. Here, we show that IQGAP1, a scaffold protein regulating AS of distinct gene subsets in gastric cancer cells, participates in AS regulation that strongly affects mitochondrial respiration. Combined proteomic and RNA-seq analyses

SUBMITTER: Papadaki V 

PROVIDER: S-EPMC10448856 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature