Neural dynamics underlying associative learning in the dorsal and ventral hippocampus.

ABSTRACT: Animals associate cues with outcomes and update these associations as new information is presented. This requires the hippocampus, yet how hippocampal neurons track changes in cue-outcome associations remains unclear. Using two-photon calcium imaging, we tracked the same dCA1 and vCA1 neurons across days to determine how responses evolve across phases of odor-outcome learning. Initially, odors elicited robust responses in dCA1, whereas, in vCA1, odor responses primarily emerged after learning and embedded information about the paired outcome. Population activity in both regions rapidly reorganized with learning and then stabilized, storing learned odor representations for days, even after extinction or pairing with a different outcome. Additionally, we found stable, robust signals across C

SUBMITTER: Biane JS 

PROVIDER: S-EPMC10448873 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature