Crown-of-thorns starfish spines secrete defence proteins.

ABSTRACT:

Background

The crown-of-thorns starfish (COTS; Acanthaster species) is a slow-moving corallivore protected by an extensive array of long, sharp toxic spines. Envenomation can result in nausea, numbness, vomiting, joint aches and sometimes paralysis. Small molecule saponins and the plancitoxin proteins have been implicated in COTS toxicity.

Methods

Brine shrimp lethality assays were used to confirm the secretion of spine toxin biomolecules. Histological analysis, followed by spine-derived proteomics helped to explain the source and identity of proteins, while quantitative RNA-sequencing and phylogeny confirmed target gene expression and relative conservation, respectively.

Results

We demonstrate the lethality of COTS spine secreted biomolecules on brine shrimp,

SUBMITTER: Hillberg AK 

PROVIDER: S-EPMC10448888 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature