Does serum neurofilament light help predict accelerated cognitive ageing in unimpaired older adults?

ABSTRACT:

Introduction

Neurofilament light (NfL) is a blood biomarker of neurodegeneration. While serum NfL levels have been demonstrated to increase with normal ageing, the relationship between serum NfL levels and normal age-related changes in cognitive functions is less well understood.

Methods

The current study investigated whether cross-sectional serum NfL levels measured by single molecule array technology (Simoa®) mediated the effect of age on cognition, measured by a battery of neuropsychological tests administered biannually for 8 years, in a cohort of 174 unimpaired older adults (≥50 years) from the Tasmanian Healthy Brain Project. Mediation analysis was conducted using latent variables representing cognitive test performance on three cognitive domains - episodic memory, exe

SUBMITTER: Collins JM 

PROVIDER: S-EPMC10448959 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature