Diagnostic significance of dysregulated miRNAs in T-cell malignancies and their metabolic roles

ABSTRACT: T-cell malignancy is a broad term used for a diverse group of disease subtypes representing dysfunctional malignant T cells transformed at various stages of their clonal evolution. Despite having similar clinical manifestations, these disease groups have different disease progressions and diagnostic parameters. The effective diagnosis and prognosis of such a diverse disease group demands testing of molecular entities that capture footprints of the disease physiology in its entirety. MicroRNAs (miRNAs) are a group of noncoding RNA molecules that regulate the expression of genes and, while doing so, leave behind specific miRNA signatures corresponding to cellular expression status in an altered stage of a disease. Using miRNAs as a diagnostic tool is justified, as they can effectively distin

SUBMITTER: Mondal D 

PROVIDER: S-EPMC10448964 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature