Effect of neonatal seizure burden and etiology on the long-term outcome: data from a randomized, controlled trial.

ABSTRACT:

Background

Neonatal seizures are common, but the impact of neonatal seizures on long-term neurologic outcome remains unclear. We addressed this question by analyzing data from an early-phase controlled trial of bumetanide to treat neonatal seizures.

Methods

Neonatal seizure burden was calculated from continuous video-EEG data. Neurologic outcome was determined by standardized developmental tests and post-neonatal seizure recurrence.

Results

Of 111 enrolled neonates, 43 were randomized to treatment or control groups. There were no differences in neurologic outcome between treatment and control groups. A subgroup analysis was performed for 84 neonates with acute perinatal brain injury (57 HIE, 18 stroke, 9 ICH), most of whom (70%) had neonatal seizures. There was a sign

SUBMITTER: Trowbridge SK 

PROVIDER: S-EPMC10449023 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature